What is the prevalence of breast cancer in the US? 147(7):441-50. [Full Text]. 32 (19):2078-99. What is the association between breast cancer and cardiovascular disease (CVD)? Endogenous insulin functions in the body in which of the following ways: a. Endocrine action only b. Mitogenic action only c. A and B . 31(25):3091-3099. [Guideline] Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, et al. John V Kiluk, MD, FACS is a member of the following medical societies: American College of Surgeons, American Society of Breast Surgeons, Moretz Surgical Society, Society of Surgical Oncology, Southeastern Surgical CongressDisclosure: Nothing to disclose. Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study. c. Level III axillary lymph nodes should be removed in all axillary lymph node dissections 2009 Jun. Phesgo (pertuzumab/trastuzumab/hyaluronidase-zzxf [package insert]. The five most common cancers that kill women are, in order of frequency, breast cancer, lung cancer, … a. [Guideline] Smith BD, Bellon JR, Blitzblau R, et al. Answer: a, c. 38. Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline. Gemcitabine plus Paclitaxel versus Paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment. What is the accuracy of breast imaging modalities for the diagnosis of breast cancer? Accessed: April 6, 2017. Severe hyperplasia. Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. Which of the following statement(s) is/are true concerning her diagnosis and management? Answer: C, 9. Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles. U.S. Food & Drug Administration. 2013 Aug. 14(8):721-40. 2. d. An isolated lesion is considered premalignant Margolese RG, Cecchini RS, Julian TB, Ganz PA, Costantino JP, Vallow LA, et al. e. Regional lymph node recurrence following axillary node dissection is rare A. Which of the following conditions is associated with increased risk of breast cancer? 2004 Apr 15. Risk factors for breast cancer according to estrogen and progesterone receptor status. Which of the following conclusion(s) can be drawn from the results of the NSABP prospective randomized trials completed in the 1970’s and 1980’s? What is the role of surgery for the treatment of metastatic breast cancer? 2007 Oct 2. [Full Text]. Olsson Möller U, Beck I, Rydén L, Malmström M. A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews. N Engl J Med. [Medline]. e. None of the above Schairer C, Lubin J, Troisi R, Sturgeon S, Brinton L, Hoover R. Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk. 2013 Jul 8. c. Pulmonary metastases are the most common initial site of distant recurrence 2003 Dec. 17(12 Suppl 14):15-21. C. If removal of 2000 gm. Question 01 . Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, et al. Answer: a, d. 37. b. Biopsy of the nipple revealing malignant cells within the milk ducts is invariably associated with an underlying invasive carcinoma 2013 Apr. Goss PE, Ingle JN, Alés-Martínez JE, Cheung AM, Chlebowski RT, Wactawski-Wende J, et al. [Full Text]. Available at http://www.medscape.com/viewarticle/849878. One third of palpable breast cancers are not detected by mammography 2008 Aug. 8(4):334-42. Allred DC, Anderson SJ, Paik S, Wickerham DL, Nagtegaal ID, Swain SM, et al. Breast cancer. What are European Commission Initiative on Breast Cancer (ECIBC) screening guidelines? 344(11):783-92. 2001 Mar 1. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. [Medline]. JAMA Intern Med. N Engl J Med. Lancet. Dickler MN, Tolaney SM, Rugo HS, Cortés J, Diéras V, Patt D, et al. 2012 Aug 2. October 20, 2018. 2004 Apr. 362(9382):419-27. J Natl Cancer Inst. Systemic Adjuvant Therapy for Breast Cancer, Treatment of Locally Advanced and Inflammatory Breast Cancer, Systemic Treatment of Metastatic Breast Cancer, Surgical Treatment of Metastatic Breast Cancer, Pharmacologic Reduction of Breast Cancer Risk, Pharmacologic Interventions for Breast Cancer Risk Reduction, Use of Biomarkers to Guide Adjuvant Systemic Therapy, Antineoplastics, Estrogen Receptor Antagonist, http://seer.cancer.gov/statfacts/html/breast.html#incidence-mortality, https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm599560.htm?utm_campaign=03062018_PR_23andme_BRCA&utm_medium=email&utm_source=Eloqua, https://www.medpagetoday.com/meetingcoverage/sabcs/83882, http://www.medscape.com/viewarticle/876981, https://www.medscape.com/viewarticle/891048, https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breast-cancer-facts-and-figures-2019-2020.pdf, http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf, http://circ.ahajournals.org/content/circulationaha/early/2018/01/31/CIR.0000000000000556.full.pdf, http://www.medscape.com/viewarticle/818267, https://www.acr.org/Advocacy-and-Economics/ACR-Position-Statements/Breast-Tomosynthesis, https://www.breastsurgeons.org/about/statements/PDF_Statements/APBI.pdf, http://www.medscape.com/viewarticle/814157, http://www.medscape.com/viewarticle/822213, http://www.medscape.com/viewarticle/849878, http://www.medscape.com/viewarticle/809174, http://www.medscape.com/viewarticle/824751, http://www.medscape.com/viewarticle/839171, https://www.novartis.com/news/media-releases/novartis-kisqalir-ribociclib-lee011-receives-fda-approval-first-line-treatment, https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm592347.htm, https://www.medscape.com/viewarticle/937073, https://www.fda.gov/drugs/drug-safety-and-availability/fda-alerts-health-care-professionals-and-oncology-clinical-investigators-about-efficacy-and, https://www.cancer.gov/types/breast/risk-reducing-surgery-fact-sheet, https://www.nccn.org/professionals/physician_gls/pdf/breast_risk.pdf, http://www.medscape.com/viewarticle/808213, http://www.medscape.com/viewarticle/862372, http://www.medscape.com/viewarticle/825727, https://wayback.archive-it.org/7993/20170111165229/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm279485.htm, http://www.medscape.com/viewarticle/811553, Hemostasis and Thrombosis Research Society, Hemophilia and Thrombosis Research Society, Association of Clinical Research Professionals, Royal College of Physicians and Surgeons of Canada, American College of Obstetricians and Gynecologists, American Institute of Ultrasound in Medicine, Association of Professors of Gynecology and Obstetrics, Central Association of Obstetricians and Gynecologists, Council of University Chairs of Obstetrics and Gynecology, Diarrhea, fatigue, neutropenia and nausea, Mean PFS was 16 months in the letrozole group and 25.3 months for ribociclib, QT prolongation, hepatobiliary toxicity, neutropenia, alopecia, diarrhea, vomiting, constipation, fatigue, anorexia, 10 mg/kg IV on Days 1 and 8 with 2 wk off, Nausea, neutropenia, diarrhea, fatigue, anemia, vomiting, Fatigue, anemia, nausea, neutropenia, headache, thrombocytopenia, vomiting, alopecia, diarrhea, and decreased appetite, Fever, allergic reaction, cardiotoxicity/congestive heart failure, Interstitial lung disease and pneumonitis; neutropenia; LVEF, Diarrhea, hand-foot syndrome, nausea, fatigue, hepatotoxicity, Repeat cycle every 3 week; continue until disease recurrence or unmanageable toxicity, whichever occurs first. Example: Which statements apply to the estrogen receptor? Answer: b, d. 19. 50:346-358. 348:g366. 2005 Jul 1. 331(1):10-5. Which of the following statement(s) is/are true concerning her diagnosis and treatment? [Full Text]. 2012 Oct 4. García-Albéniz X, Hernán MA, Logan RW, Price M, Armstrong K, Hsu J. Answer: b. What are the ASCO criteria for postmastectomy radiation therapy in the treatment of breast cancer? Cancer statistics, 2020. 20(12):2812-23. Treatment is with warm compresses and oral antibiotics Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation. J Clin Oncol. An adult man was diagnosed with colon cancer with skeletal and hepatic metastases. ACR Statement on Breast Tomosynthesis. Distended duct with intact basement membrane and central tumor necrosis. Pharmacogenomics. Increased thymidine labeling index, a measure of the proportion of cells in the DNA synthetic phase (S-phase), is associated with improved survival 279(6):881-90. Treatment options for breast cancer partly depend on how small or large your tumor is, if the cancer has spread to the lymph nodes and if the cancer is found in other parts of your body. Prognostic markers for invasive micropapillary carcinoma of the breast: a population-based analysis. Lancet. 2017 Oct. 35:203-217. [Medline]. What is the role of PET scanning in the workup of breast cancer? 2002 Jun 27. a. 2011 Nov 20. Breast J. 2015 Oct 20. Adjuvant Endocrine Therapy for Women With Hormone Receptor-Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update on Ovarian Suppression. 32 (13):1365-83. [Medline]. [Full Text]. Cancer Epidemiol Biomarkers Prev. This lesion is the most common cause of bloody nipple discharge 2020 Feb 25. 2005 Jul. [Full Text]. How is locally advanced breast cancer (LABC) and inflammatory breast cancer (IBC) treated? [Medline]. 1997 Mar. [Medline]. Chustecka Z. FDA Warning on Nipple Aspirate Test as Breast Cancer Screen. b. Haviland JS, Owen JR, Dewar JA, et al, on behalf of the START Trialists' Group. 2-cm. [156] HER2-positive metastatic breast cancer regimens What are the ASBrS selection criteria for treatment of breast cancer with accelerated partial breast irradiation (PBI)? J Clin Oncol. [Full Text]. Ann Intern Med. Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, et al. [Full Text]. 2001 Mar 15. [Medline]. 2015 Jul 20. d. There is no evidence to suggest a role for chemotherapy in node-negative patients Available at https://www.nccn.org/professionals/physician_gls/pdf/breast_risk.pdf. If you log out, you will be required to enter your username and password the next time you visit. 2005 Apr. d. The local recurrence rate following breast-conserving procedures varies from 10% to 40% whether or not radiation was used What is the efficacy of 3D mammography for breast cancer screening? [Medline]. [Full Text]. B. Mitotic count/HPF (microscope- and field-dependent), Grade I cancer if total score (A + B + C) is 3-5, Grade II cancer if total score (A + B + C) is 6 or 7, Grade III cancer if total score (A + B + C) is 8 or 9, Paget disease of the nipple NOT associated with invasive carcinoma and/or carcinoma in situ (DCIS) in the underlying breast parenchyma. What type of test will a physician conduct to diagnose the cancer a) blood test b) pap test c) CT scan d) mammography 13. a. b. Tamoxifen clearly improves survival in all hormonal receptor-positive patients [Full Text]. [Medline]. Extensive intraductal cancer around the invasive lesion. Breast Cancer Risk Reduction. Medication Use to Reduce Risk of Breast Cancer: US Preventive Services Task Force Recommendation Statement. Chaudary MA, Millis RR, Lane EB, Miller NA. Kollias J, Ellis IO, Elston CW, Blamey RW. True B. 2020 Jan. 70 (1):7-30. N Engl J Med. Siegel RL, Miller KD, Jemal A. 9(3):R28. 2014 May 5. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). 2016 Apr 1. J Clin Oncol. JAMA Oncol. What is the role of reproductive factors in the etiology of breast cancer? Consensus Guideline on Accelerated Partial Breast Irradiation. [Full Text]. Answer: C, 3. Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, et al. What is the efficacy of external-beam radiotherapy (EBRT) in the treatment of breast cancer? June 5, 2018; Accessed: January 17, 2019. [Medline]. Choose your answers from a-d by clicking the radio button next to each choice and then press 'Submit' to get your score. What is the pathophysiology of breast cancer? Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, et al. [Full Text]. What are the racial predilections of breast cancer? 2013 Aug 10. 2004 Feb. 150(2):161-71. 2018. March 6, 2018; Accessed: March 8, 2018. Arch Intern Med. [Medline]. Some people if diagnoses at the advanced stages have a lower probability of surviving the disease. 1998 Nov. 34(12):1852-6. The American Cancer Society recommends that men have a chance to make an informed decision with their health care provider about whether to be checked for prostate cancer. Int J Cancer. e. Post-menopausal use of conjugated estrogens Effect of screening and adjuvant therapy on mortality from breast cancer. PALOMA-3: Phase III Trial of Fulvestrant With or Without Palbociclib in Premenopausal and Postmenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer That Progressed on Prior Endocrine Therapy-Safety and Efficacy in Asian Patients. b. Medullary carcinomas, although often of large size, are associated with a better overall prognosis than common invasive ductal cancers 1994 Aug 11. According to ASCO guidelines, which patients with breast cancer should be offered sentinel lymph node (SLN) biopsy? Herceptin [package insert]. [Medline]. 363(9407):453-5. The most common organism which would expect to be cultured is Staphylococcus aureus 2014. The percentage of patients with chest wall recurrence as their initial site of failure following mastectomy is similar for node-negative and node-positive patients Clin Breast Cancer. What are the histologic findings of medullary carcinoma breast cancer? Breast. Moyer VA, U.S. Preventive Services Task Force. [Medline]. 2006 Dec 1. Benefit of adjuvant brachytherapy versus external beam radiation for early breast cancer: impact of patient stratification on breast preservation. [Medline]. Breast reconstruction may interfere with detection of local recurrence of breast cancer Weight, dietary behavior, and physical activity in childhood and adolescence: implications for adult cancer risk. [Full Text]. What are the histologic findings of mucinous carcinoma breast cancer? Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, et al. Breast cancer can be treated by surgery, radiation, hormone therapy, and chemotherapy. C. Tumor size greater than 3 cm. The majority of patients recur within five years of diagnosis J Clin Oncol. 30(12):1268-73. 2005 Mar 9. Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27. c. Use of oral contraceptives [Medline]. [Medline]. [Full Text]. Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer. The Multiple Choice Question test (MCQ test) consists of up to 150 questions. What is the role of single-dose radiotherapy in the treatment of breast cancer? Anderson WF, Reiner AS, Matsuno RK, Pfeiffer RM. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Ann Intern Med. 2013 May 14. Baselga J, Seidman AD, Rosen PP, Norton L. HER2 overexpression and paclitaxel sensitivity in breast cancer: therapeutic implications. E. hCG. Answer: a, c. 22. Which medications in the drug class Antineoplastics, Antimetabolite are used in the treatment of Breast Cancer? Breast Cancer Res. What are guidelines for HRT in women at high risk of breast cancer? Which of the following statement(s) is/are associated with gynecomastia? Modi S, Saura C, Yamashita T, and the, DESTINY-Breast01 Investigators. Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, et al. According to ACOG guidelines, which breast cancer risk factors should be periodically assessed in women? A permanent prosthesis or tissue expander may be inserted at the time of the ablative surgery. JAMA. Garbe E, Levesque L, Suissa S. Variability of breast cancer risk in observational studies of hormone replacement therapy: a meta-regression analysis. Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. This activity contains 18 questions. FDA approves first treatment for breast cancer with a certain inherited genetic mutation. All biopsy specimens should be transported to pathology in formalin within 24 hours of the procedure [Guideline] NCCN Clinical Practice Guidelines in Oncology. [Medline]. Ann Intern Med. 151 (10):716-26, W-236. [Medline]. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. Which of the following statement(s) is/are correct concerning prognostic factors for breast carcinoma? 2011 Jun 23. MCQ Examination Choice the single best answer 1- Which of the following statements is FALSE regarding laryngeal carcinoma? 12(5):496-503. [Medline]. What is the efficacy of breast cancer screening in the early detection of breast cancer? 82(1):186-95. [Full Text]. Which of the following treatment adjustments is most appropriate … 2016 Dec 17. Adjuvant therapy benefits all patients and is independent of age or node status. 331(6):347-52. b. Beral V. Breast cancer and hormone-replacement therapy in the Million Women Study. What are the systemic treatments for metastatic breast cancer? 2001 Sep. 14(9):836-41. Breast cancer. A 42-year-old woman undergoes her first mammogram. Anderson GL, Chlebowski RT, Aragaki AK, Kuller LH, Manson JE, Gass M, et al. What are the USPSTF guidelines for BRCA-related breast cancer screening? What are ASCO guidelines for monitoring bone density following the treatment for breast cancer? How can you stay calm? N Engl J Med. 2017 Sep 1. b) For most women a specific cause of their breast cancer is known. b. Frozen-section examination is particularly useful in the diagnosis of this lesion 130 (1):e1-e16. c. Intense interlobular fibrosis and proliferation of small ductules with loss of orientation of lobules and epithelial cells may suggest carcinoma C. Incisional biopsy with an involved margin, followed by radiation. 35 (32):3638-3646. Narod SA, Iqbal J, Giannakeas V, Sopik V, Sun P. Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma In Situ. What is the role of mammography in the workup of breast cancer? Available at http://circ.ahajournals.org/content/circulationaha/early/2018/01/31/CIR.0000000000000556.full.pdf. Novel Drug Approved for Breast Cancer: Palbociclib (Ibrance). 2019 Sep 30. [Medline]. Hankinson SE, Eliassen AH. 375 (18):1738-1748. What is the prognosis of mammary Paget disease? d. Milky breast discharge would not be expected one year after discontinuation of breast feeding Breast cancer and the western diet: role of fatty acids and antioxidant vitamins. Which medications in the drug class Aromatase Inhibitors are used in the treatment of Breast Cancer? What are the ASCO guidelines for the use of hormonal adjuvant therapy in the treatment of premenopausal women with breast cancer? New Guidelines on Chemoprevention for Breast Cancer. Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M, et al. Ann Intern Med. Which age groups have the highest prevalence of breast cancer? Smith-Bindman R. Environmental causes of breast cancer and radiation from medical imaging: findings from the Institute of Medicine report. Albain KS, Nag SM, Calderillo-Ruiz G, Jordaan JP, Llombart AC, Pluzanska A, et al. 2002 Jun 15. [Medline]. 2002 Apr 17. Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial. [Medline]. Robertson JFR, Bondarenko IM, Trishkina E, Dvorkin M, Panasci L, Manikhas A, et al. Most Asked Technical Basic CIVIL | Mechanical | CSE | EEE | ECE | IT | Chemical | Medical MBBS Jobs Online Quiz Tests for Freshers Experienced. National Cancer Institute. a. [Medline]. What are the ACOG guidelines for clinical breast exam to screen for breast cancer? What are the NCCN guidelines for fine needle aspiration (FNA) and core biopsy in the treatment of breast cancer? 361(9352):125-9. CA Cancer J Clin. Breast Cancer Res. Breast cancer. Breast Cancer Res. [Medline]. 2015. 17 (3):367-77. [Guideline] Partridge AH, Rumble RB, Carey LA, Come SE, Davidson NE, Di Leo A, et al. 2014 Feb 11. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. J Natl Cancer Inst. Anatomy of the breast. Lancet. Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. What are the ASCO guidelines on pharmacologic interventions for breast cancer risk reduction? 2014 Jul 20. 379 (8):753-763. [Medline]. 2016 Mar. [Medline]. What are the histologic findings of tubular carcinoma breast cancer? What is included in the evaluation of breast cancer? C. Adjuvant therapy does not work in estrogen-positive patients. Lancet. B. Which one of the following genes is involved in the conversion of proto-oncogenes into oncogenes causing cancer? A. Answer: b, d. 20. [Medline]. N Engl J Med. Authors; Authors and affiliations; Lynda Wyld; Christos Markopoulos; Chapter. Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task Force. 172(13):1023-7. 2005. [Medline]. What is the efficacy of combination therapy in the treatment of triple-negative breast cancer? [Full Text]. [Medline]. The total dose given to the breast is usually in the range of 2500 to 3000 cGy [Medline]. c. The sensitivity of mammography increases with age 15(3):281-7. What is the prognosis of locally advanced breast cancer (LABC) and inflammatory breast cancer (IBC) following treatment? 2014 Feb 1. 152(10):950-64. 17:47-67. What are ACS guidelines for the use of MRI in breast cancer screening? [Medline]. Available at https://www.acr.org/Advocacy-and-Economics/ACR-Position-Statements/Breast-Tomosynthesis. Which of the following are true of breast cancer? BMJ. 26(24):3950-7. [Medline]. A. [Guideline] Wilt TJ, Harris RP, Qaseem A, et al. of breast tissue is needed, breast amputation with immediate free nipple-areola grafting is performed. 377 (6):523-533. [Medline]. a. Mammography will play an important role in diagnosing the lesion [Medline]. 2005 Nov 15. Fareston [package insert]. Lancet Oncol. [Full Text]. Levels of vitamin B 12. Once you have completed the test, click on ''Submit Answers for Grading'' to get your results. John V Kiluk, MD, FACS Associate Professor, Department of Oncologic Sciences, Department of Surgery (Joint Appointment), University of South Florida Morsani College of Medicine; Clinical Director, Breast Surgical Oncology, Associate Member, Comprehensive Breast Program, Department of Women's Oncology, H Lee Moffitt Cancer Center and Research Institute Answer: B, 11. A. Grade 3, poorly differentiated, infiltrating ductal carcinoma. Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. How is HER2 testing performed in the evaluation of breast cancer? Answer: a, c. 35. 2006 Jul 12. 1999 Apr. 2015 Jan. 16(1):25-35. Breast Cancer Res Treat. 2002 Sep 3. ... 10- A 20 year old women presents to the breast clinic with a firm painful 2 cm lump in the upper outer quadrant of the right breast. [Guideline] Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, et al. [Full Text]. Medscape Medical News. This time frame includes transfer of the individual answer codes to the evaluation form. Available at https://www.medpagetoday.com/meetingcoverage/sabcs/83882. Which of the following statement(s) is/are true concerning her management? Answer: a, d. 32. What is the MammaPrint assay for breast cancer? Carcinomas in the breast parenchyma associated with Paget disease are categorized on the basis of the size and characteristics of the parenchymal disease, although the presence of Paget disease should still be noted, Tumor > 1 mm but ≤ 5 mm in greatest dimension (round any measurement >1.0-1.9 mm to 2 mm), Tumor > 5 mm but ≤ 10 mm in greatest dimension, Tumor > 10 mm but ≤ 20 mm in greatest dimension, Tumor > 20 mm but ≤ 50 mm in greatest dimension, Tumor of any size with direct extension to the chest wall and/or to the skin (ulceration or skin nodules), not including invasion of dermis alone, Extension to chest wall, not including only pectoralis muscle adherence/invasion, Ulceration and/or ipsilateral satellite nodules and/or edema (including peau d’orange) of the skin, which do not meet the criteria for inflammatory carcinoma, Regional lymph nodes cannot be assessed (eg, previously removed), No regional lymph node metastasis (on imaging or clinical examination), Metastasis to movable ipsilateral level I, II axillary lymph node(s), Micrometastases (approximately 200 cells, larger than 0.2 mm, but none larger than 2.0 mm), Metastases in ipsilateral level I, II axillary lymph nodes that are clinically fixed or matted; or in ipsilateral internal mammary nodes in the absence of clinically evident axillary lymph node metastases, Metastases in ipsilateral level I, II axillary lymph nodes fixed to one another (matted) or to other structures, Metastases only in ipsilateral internal mammary nodes and in the absence of axillary lymph node metastases, Metastases in ipsilateral infraclavicular (level III axillary) lymph node(s), with or without level I, II axillary node involvement, or in ipsilateral internal mammary lymph node(s) with level I, II axillary lymph node metastasis; or metastases in ipsilateral supraclavicular lymph node(s), with or without axillary or internal mammary lymph node involvement, Metastasis in ipsilateral infraclavicular lymph node(s), Metastasis in ipsilateral internal mammary lymph node(s) and axillary lymph node(s), Metastasis in ipsilateral supraclavicular lymph node(s). What is the role of estradiol in the etiology of breast cancer? 1998. Lancet Oncol. Answer: a, b, d. 18. 2/7 Hx of nausea and thirst. [Medline]. What are the USPSTF guidelines on risk assessment for BRCA-related breast cancer? Which of the following statement(s) is/are true concerning mammography? b. Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. Henderson BE, Bernstein L. The international variation in breast cancer rates: an epidemiological assessment. [Medline]. Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer. Medscape Medical News. c. The response to chemotherapy will likely be dose-dependent Up to 50% of cancers detected mammographically are not palpable Included topics in this NCLEX practice questions (with rationales) for cancer and oncology nursing are: oncology nursing, Hodgkin’s disease, lung cancer, nursing care of patients undergoing chemotherapy, brachytherapy, laryngeal cancer, colon cancer, and more! Selection of Optimal Adjuvant Chemotherapy Regimens for Early Breast Cancer and Adjuvant Targeted Therapy for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancers: An American Society of Clinical Oncology Guideline Adaptation of the Cancer Care Ontario Clinical Practice Guideline. d. Dermal lymphatic invasion Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer. JAMA. 2017 Jul. Medscape Medical News. Grading System in Invasive Breast Cancer (Modified Bloom and Richardson), Table 3. 200 mg PO BID continue until disease progression, 1250 mg/m²/d PO for 2 weeks with 1 wk off, Less cardiotoxicity, neutropenia, alopecia, stomatitis, hand-foot, Myelosuppression, mucositis, nausea, vomiting, cardiotoxicity, Mean PFS was 10.2 months in the letrozole group and 20.2 months for palbociclib plus letrozole group, Neutropenia, leukopenia, thrombocytopenia, anemia, stomatitis, Combination therapy: 4 mg/kg IV once, then 2 mg/kg weekly for 12-18 weeks, then 6 mg/kg q3weeks to total 52 weeks, 500 mg IM on days 1, 15, 29 and once monthly thereafter, 500 mg IM on Days 1, 15 and 29 and once monthly thereafter, HER2-positive metastatic breast cancer regimens, Loading dose of 1,200 mg pertuzumab/600 mg trastuzumab SC x 1 dose followed by 600 mg pertuzumab/600 mg trastuzumab SC, Docetaxel is 75 mg/m2 IV, may escalate to 100 mg/m2, AUC = area under the curve (systemic exposure), References for chemotherapy regimens: XT, Chustecka Z. [Medline]. a. Smith RA, Andrews K, Brooks D, DeSantis CE, Fedewa SA, Lortet-Tieulent J, et al. [Medline]. [Medline]. J. Gemcitabine combination chemotherapy in metastatic breast cancer develops an erythematous and inflamed fluctuant on. Consensus guidelines for sentinel lymph node biopsy ( SLNB ) in breast cancer, its symptoms, and breast screening..., Kirshner JJ, et al circulating sex steroids and breast cancer, Rich-Edwards JW, et.... Mastectomy for breast cancer EP, fisher b, Domchek SM, Gelman RS, Cronin WM et! For postmastectomy radiation therapy for women with Dense Breasts at high risk and lesions., Dewar JA, Wilson HG, MacLennan AH, Missmer SA, Prummel MV, Muradali D Barbieri! Jg, Armstrong K, Hurley P, to T, and physical in. A small region of chromosome 13q12-13 of American Pathologists Guideline recommendations for contralateral prophylactic mastectomy ( CPM consensus! 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